Efecto de donepezil en la función motora y cognitiva en la enfermedad de Huntington

Categoría Estudio primario
RevistaNeurology
Año 2006
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Striatal cholinergic dysfunction may be important in Huntington disease (HD). We studied whether donepezil improves chorea, cognition, and quality of life (QoL) in HD. Thirty patients were randomly assigned to treatment with donepezil or placebo. At the doses studied, donepezil did not improve chorea, cognition, or QoL. Adverse events were similar between both groups. Based on this small sample study, donepezil was not an effective treatment for HD.
Epistemonikos ID: 2e98a33479e93a771418c5094fdf510ac9fc2ebd
First added on: Jan 16, 2015