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Estudio primario

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Effect of supplemental oxygen exposure on myocardial injury in ST-elevation myocardial infarction.

Revista Heart (British Cardiac Society)
Año 2016
Enlaces Pubmed DOI

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OBJECTIVE: Supplemental oxygen therapy may increase myocardial injury following ST-elevation myocardial infarction (STEMI). In this study, we aimed to evaluate the effect of the dose and duration of oxygen exposure on myocardial injury after STEMI. METHODS: Descriptive analysis of data from a multicentre, prospective, randomised, controlled trial of 441 patients with STEMI randomised to supplemental oxygen therapy or room air breathing. The primary endpoint was myocardial infarct size as assessed by cardiac biomarkers, troponin (cTnI) and creatine kinase (CK). Oxygen therapy was commenced by paramedics, and continued for up to 12 h postintervention in hospital. Supplemental oxygen exposure was calculated as the area under the dose×time curve for oxygen administration over the first 12 h, and then assessed for its association with cTnI/CK release using multivariable linear regression. RESULTS: The median supplemental oxygen exposure was 1746 L (IQR: 960-2858). After adjustment for potential confounders, every 100 L increase in oxygen exposure in the first 12 h was associated with a 1.4% (95% CI 0.6% to 2.2%, p<0.001) and 1.2% (95% CI 0.7% to 1.8%, p<0.001) increase in the mean peak cTnI and CK, respectively. Excluding patients who developed cardiogenic shock, recurrent myocardial infarction or desaturations (SpO2<94%) during admission, every 100 L increase in oxygen exposure was associated with a 1.2% (95% CI 0.2% to 2.1%, p=0.01) and 1.0% (95% CI 0.3% to 1.7%, p=0.003) increase in the mean peak cTnI and CK, respectively. The median supplemental oxygen exposure of 1746 L would result in a 21% (95% CI 3% to 37%) increase in infarct size according to the cTnI profile. CONCLUSIONS: Supplemental oxygen exposure in the first 12 h after STEMI was associated with a clinically significant increase in cTnI and CK release.

Estudio primario

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Air Versus Oxygen in ST-Segment-Elevation Myocardial Infarction.

Revista Circulation
Año 2015
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Este artículo está incluido en 1 Revisión sistemática Revisiones sistemáticas (1 referencia) 1 Síntesis amplia Síntesis amplias (1 referencia)

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BACKGROUND: Oxygen is commonly administered to patients with ST-elevation-myocardial infarction despite previous studies suggesting a possible increase in myocardial injury as a result of coronary vasoconstriction and heightened oxidative stress. METHODS AND RESULTS: We conducted a multicenter, prospective, randomized, controlled trial comparing oxygen (8 L/min) with no supplemental oxygen in patients with ST-elevation-myocardial infarction diagnosed on paramedic 12-lead ECG. Of 638 patients randomized, 441 patients had confirmed ST-elevation-myocardial infarction and underwent primary end-point analysis. The primary end point was myocardial infarct size as assessed by cardiac enzymes, troponin I, and creatine kinase. Secondary end points included recurrent myocardial infarction, cardiac arrhythmia, and myocardial infarct size assessed by cardiac magnetic resonance imaging at 6 months. Mean peak troponin was similar in the oxygen and no oxygen groups (57.4 versus 48.0 μg/L; ratio, 1.20; 95% confidence interval, 0.92-1.56; P=0.18). There was a significant increase in mean peak creatine kinase in the oxygen group compared with the no oxygen group (1948 versus 1543 U/L; means ratio, 1.27; 95% confidence interval, 1.04-1.52; P=0.01). There was an increase in the rate of recurrent myocardial infarction in the oxygen group compared with the no oxygen group (5.5% versus 0.9%; P=0.006) and an increase in frequency of cardiac arrhythmia (40.4% versus 31.4%; P=0.05). At 6 months, the oxygen group had an increase in myocardial infarct size on cardiac magnetic resonance (n=139; 20.3 versus 13.1 g; P=0.04). CONCLUSION: Supplemental oxygen therapy in patients with ST-elevation-myocardial infarction but without hypoxia may increase early myocardial injury and was associated with larger myocardial infarct size assessed at 6 months. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01272713.

Estudio primario

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Air versus oxygen in myocardial infarction (AVOID) trial sub-study: Time-dependent effect of oxygen administration on myocardial injury

Revista Heart, Lung and Circulation
Año 2015
Enlaces DOI

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Background: Routine oxygen therapy has been associated with increased myocardial injury following acute myocardial infarction, although the time-dependent effect of oxygen administration on myocardial infarct size has not been evaluated. Methods: This was a planned sub-study of the Australian multicentre, prospective, randomised, controlled AVOID trial, of 441 STEMI patients who were allocated to routine oxygen therapy (8L/min via facemask) or no supplemental oxygen. The primary endpoint was myocardial infarct size as assessed by cardiac enzymes, troponin (cTnI) and creatine kinase (CK). Allocated treatment was commenced by paramedics after randomisation, and continued for up to 12 hours post procedural intervention in hospital. Peak and are under the curve for cTnI and CK and were assessed using linear regression models adjusted for age, gender, pre-intervention TIMI flow, Killip class, culprit artery, and symptom-to-intervention time. Results: Pre-intervention oxygen administration was not associated with peak cTnI or peak CK release. After adjustment, when compared to no oxygen administration, longer durations of post-intervention oxygen therapy were associated with higher ratios ofmeanpeak cTnI (≤2 hours: 1.43 [95% CI: 0.99 to 2.08, p=0.059]; 2-6 hours: 1.67 [95% CI: 1.14 to 2.44, p=0.009]; 6-12 hours: 2.05 [95% CI: 1.30 to 3.24, p=0.002] and mean peak CK (≤2 hours: 1.22 [95% CI: 0.95 to 1.78, p=0.120]; 2-6 hours: 1.31 [95% CI: 1.01 to 1.71, p=0.043]; 6-12 hours: 1.62 [95% CI: 1.19 to 2.22, p=0.002]. Conclusion: In patients with STEMI, longer durations of oxygen therapy post-procedural intervention may be associated with increased myocardial injury.

Estudio primario

No clasificado

Air versus oxygen in ST-elevation myocardial infarction

Autores Stub, D , Smith, K , Bernard, S
No publicado clinicaltrialresults.org
Año 2015
Enlaces clinicaltrialresults.org

Este artículo está incluido en 1 Revisión sistemática Revisiones sistemáticas (1 referencia) 1 Síntesis amplia Síntesis amplias (1 referencia)

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Avoid methods and experience of initial randomisations

Revista Academic Emergency Medicine
Año 2012

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Estudio primario

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A randomized controlled trial of oxygen therapy in acute myocardial infarction Air Verses Oxygen In myocarDial infarction study (AVOID Study).

Revista American heart journal
Año 2012
Enlaces Pubmed DOI

Este artículo está incluido en 2 Revisiones sistemáticas Revisiones sistemáticas (2 referencias) 1 Síntesis amplia Síntesis amplias (1 referencia)

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BACKGROUND: The role of routine supplemental oxygen for patients with uncomplicated acute myocardial infarction (AMI) has recently been questioned. There is conflicting data on the possible effects of hyperoxia on ischemic myocardium. The few clinical trials examining the role of oxygen in AMI were performed prior to the modern approach of emergent reperfusion and advanced medical management. METHODS: Air Verses Oxygen In myocarDial infarction study (AVOID Study) is a prospective, multi-centre, randomized, controlled trial conducted by Ambulance Victoria and participating metropolitan Melbourne hospitals with primary percutaneous coronary intervention capabilities. The purpose of the study is to determine whether withholding routine supplemental oxygen therapy in patients with acute ST-elevation myocardial infarction but without hypoxia prior to reperfusion decreases myocardial infarct size. AVOID will enroll 490 patients, >18 years of age with acute ST-elevation myocardial infarction of less than 12 hours duration. CONCLUSIONS: There is an urgent need for clinical trials examining the role of oxygen in AMI. AVOID will seek to clarify this important issue. Results from this study may have widespread implications on the treatment of AMI and the use of oxygen in both the pre-hospital and hospital settings.

Estudio primario

No clasificado

Air Versus Oxygen In myocarDial infarction (AVOID) study: trial methods and experience from initial randomisation

Revista Australasian Journal of Paramedicine
Año 2012

Este artículo está incluido en 1 Revisión sistemática Revisiones sistemáticas (1 referencia) 1 Síntesis amplia Síntesis amplias (1 referencia)

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Estudio primario

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[Efecto de la oxigenoterapia en combinación con la reperfusión en los pacientes con] el infarto agudo de miocardio

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Revista Kardiologiia
Año 2005
Enlaces Pubmed

Este artículo está incluido en 3 Revisiones sistemáticas Revisiones sistemáticas (3 referencias) 1 Síntesis amplia Síntesis amplias (1 referencia)

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Estudio primario

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Oxygen therapy in combination with endovascular reperfusion during the first hours of acute myocardial infarction:clinical and laboratory findings.

Revista Международный журнал интервенционной кардиоангиологии (International Journal of Interventional Cardioangiology)
Año 2005
Enlaces cyberleninka.ru

Este artículo está incluido en 2 Revisiones sistemáticas Revisiones sistemáticas (2 referencias)

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