El efecto de diferentes dosis de adefovir dipivoxil en la función renal

OBJECTIVE:

To study the effect of different doses of adefovir dipivoxil on renal function of patients with chronic hepatitis B(CHB).

METHODS:

Renal function of 309 patients with CHB who were treated with different doses of adefovir dipivoxil was examined and compared with 276 CHB patients who were not treated with adefovir dipivoxil.The doses of adefovir dipivoxil were half dose,constant dose,1.5 times doses and double doses.

RESULTS:

There was no significant difference in the abnormal rate of creatinine between the constant group and the control group(2.46% vs.2.53%),while the abnormal rate of creatnine in the double doses group was remarkable higher than that in the constant group(2.46% vs.5.48%,P0.001).If choosing the concentration of uric acid more than 430 μmol /L as abnormal,the abnormal rate of uric acid in constant group was significant higher than that in double doses group(9.36% vs 5.48%,P0.01).However,if the concentration of uric acid more than 392 μmol /L was set as abnormal,there was no significant difference of abnormal rate of uric acid among control group,constant group and double doses group (10.5%,12.8% and 10.96% respectively,P0.05). Compared with control group,both of abnormal rates of urea nitrogen in half dose group and 1.5 times doses group were significantly different(19.05% vs 14.28% and 4.71% vs 14.28% respectively).

CONCLUSION:

The major impact of adefovir dipivoxil on renal function is that double doses of adefovir dipivoxil might induce elevation of creatinine value with 5.48%. Regular monitoring renal function could guranteed safety of long term treatment of high-dose adefovir dipivoxil.The cut-off value of renal function should follow uniform labrotory standard in different units.