Broad syntheses related to this topic

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Broad synthesis / Guideline / Systematic review

Unclassified

Tijdschrift Chest
Year 2017
BACKGROUND: Acute cough associated with the common cold (CACC) causes significant impairment in quality of life. Effective treatment approaches are needed for CACC. We conducted a systematic review on the management of CACC to update the recommendations and suggestions of the CHEST 2006 guideline on this topic. METHODS: This systematic review of randomized controlled trials (RCTs) asked the question: Is there evidence of clinically relevant treatment effects for pharmacological or non-pharmacological therapies in reducing the duration/severity of acute CACC? Studies of adults and pediatric patients with CACC were included and assessed for relevance and quality. Based upon the systematic review, guideline suggestions were developed and voted on using the American College of Chest Physicians organization methodology. RESULTS: Six systematic reviews and four primary studies identified from updated literature searches for each of the reviews or from hand searching were included and reported data on 6,496 participants with CACC who received one or more of a variety of interventions. The studies used an assortment of descriptors and assessments to identify CACC. CONCLUSIONS: The evidence supporting the management of CACC is overall of low quality. This document provides treatment suggestions based on the best currently available evidence, and identifies gaps in our knowledge and areas for future research.

Broad synthesis / Living FRISBEE

Unclassified

Auteurs Nitsche MP , Carreño M
Tijdschrift Medwave
Year 2016
Cough represents one of the most common reasons for pediatrician consultations. There are many available treatments for symptomatic relief, including honey. Despite its wide availability, there is little knowledge about its benefits. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified three systematic reviews including three randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded the use of honey probably decreases the severity and frequency of cough, improves the quality of parent's and patient's sleep, and does not have side effects.

Broad synthesis / Overview of systematic reviews

Unclassified

Auteurs Hunt K , Ernst E
Tijdschrift Archives of disease in childhood
Year 2011
ACHTERGROND: Het gebruik van complementaire en alternatieve geneeskunde (CAM) bij kinderen komt vaak nog tot op heden is er geen synthese van het bewijs van de effectiviteit in deze populatie. Dit overzicht van systematische review evalueert het bewijs voor of tegen de effectiviteit van CAM voor een kind staat. METHODEN: Medline, Amed en Cochrane werden doorzocht van begin tot september 2009. Referentielijsten van gevonden artikelen werden met de hand gefouilleerd. Experts op het gebied van CAM werden gecontacteerd. Geen enkele taal beperkingen werden toegepast. RESULTATEN: 17 systematische reviews zijn opgenomen in dit overzicht, met betrekking tot acupunctuur, chiropractie, kruidengeneeskunde, homeopathie, hypnotherapie, massage en yoga. De resultaten waren niet overtuigend in de meeste omstandigheden, hoewel er ook aanwijzingen dat acupunctuur effectief kan zijn voor de postoperatieve misselijkheid en braken, en dat hypnotherapie effectief kan zijn bij het verminderen van de procedure-gerelateerde pijn. Het merendeel van de recensies niet aan de incidentie van bijwerkingen van de CAM's te noemen. Conclusie Hoewel er een aantal bemoedigende bewijs voor hypnose, fytotherapie en acupunctuur, is er onvoldoende bewijs om te suggereren dat andere CAM's zijn effectief voor de behandeling van kinderen omstandigheden. Veel van de systematische reviews opgenomen in dit overzicht zijn van lage kwaliteit, net als de gerandomiseerde klinische studies binnen deze recensies, verdere vermindering van het gewicht van dat bewijs. Toekomstig onderzoek in de CAM voor kinderen moet voldoen aan de rapportage normen beschreven in de Consort en PRISMA richtlijnen.

Broad synthesis

Unclassified

Auteurs Arroll B
Tijdschrift Clinical evidence
Year 2011
INTRODUCTION: Each year, children suffer up to 5 colds and adults have two to three infections, leading to time off school or work, and considerable discomfort. Most symptoms resolve within 1 week, but coughs often persist for longer. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for common cold? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2010 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 21 systematic reviews and RCTs that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: analgesics or anti-inflammatory drugs, antibiotics, antihistamines, decongestants for short-term and for long-term relief, decongestants plus antihistamines, echinacea, steam inhalation, vitamin C, and zinc (intranasal gel or lozenges).

Broad synthesis

Unclassified

Auteurs Ernst E
Tijdschrift Annals of internal medicine
Year 2002
Because use of herbal remedies is increasing, a risk-benefit profile of commonly used herbs is needed. This article provides a clinically oriented overview of the efficacy and safety of ginkgo, St. John's wort, ginseng, echinacea, saw palmetto, and kava. Wherever possible, assessments are based on systematic reviews of randomized clinical trials. Encouraging data support the efficacy of some of these popular herbal medicinal products, and the potential for doing good seems greater than that for doing harm. The published evidence suggests that ginkgo is of questionable use for memory loss and tinnitus but has some effect on dementia and intermittent claudication. St. John's wort is efficacious for mild to moderate depression, but serious concerns exist about its interactions with several conventional drugs. Well-conducted clinical trials do not support the efficacy of ginseng to treat any condition. Echinacea may be helpful in the treatment or prevention of upper respiratory tract infections, but trial data are not fully convincing. Saw palmetto has been shown in short-term trials to be efficacious in reducing the symptoms of benign prostatic hyperplasia. Kava is an efficacious short-term treatment for anxiety. None of these herbal medicines is free of adverse effects. Because the evidence is incomplete, risk-benefit assessments are not completely reliable, and much knowledge is still lacking.