Jensen CL
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影响产妇对母乳喂养的视觉功能和足月儿的神经发育DHA摄取。

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期刊 The American journal of clinical nutrition
Year 2005
連結 Pubmed DOI
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背景：正常的大脑和视力发育的需要外源被认为是二十二碳六烯酸（DHA，22:6的N - 3）的摄入量，但数量需要的是有争议的。由于哺乳的母亲与DHA增加了他们的婴儿补充血浆脂质DHA的含量，我们推测，它可能还可以提高婴儿脑部或者视觉功能。目标：目标是确定的DHA对神经发育母乳喂养的地位和在接受婴儿视功能的母亲补充作用。设计：哺乳期妇女或者收到胶囊含高DHA的海藻油（约200毫克DHA / d）或蔬菜油4月交货后（无DHA）的。结果变量包括产妇血浆磷脂脂质4月和牛奶产后，血浆磷脂和婴幼儿的视觉功能在4月和8岁的脂肪酸模式，并在婴儿神经发育指标12和30月脂肪酸模式年龄。结果：牛奶和婴儿血浆磷脂脂质DHA含量的补充和对照组分别约为75％及约35％以上，分别在4月产后。然而，无论是在12个月的年龄，也不是视觉功能在4月或8岁组之间差异显着婴儿的神经发育指标。与此相反，贝利运动发育指数，而不是心理发展指数，该补充组升高（P <0.01）在30岁的莫。结论：哺乳期间补充DHA的补充和运动发育指数高贝利在30岁，但在没有其他优势，结果导致钼母亲的幼儿血浆磷脂DHA含量AT或在此之前的时代。

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Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breast-fed term infants

期刊 The Journal of pediatrics
Year 2010
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Objective: We previously reported better psychomotor development at 30 months of age in infants whose mothers received a docosahexaenoic acid (DHA) (22:6n-3) supplement for the first 4 months of lactation. We now assess neuropsychological and visual function of the same children at 5 years of age. Study design: Breastfeeding women were assigned to receive identical capsules containing either a high-DHA algal oil (∼200 mg/d of DHA) or a vegetable oil (containing no DHA) from delivery until 4 months postpartum. Primary outcome variables at 5 years of age were measures of gross and fine motor function, perceptual/visual-motor function, attention, executive function, verbal skills, and visual function of the recipient children at 5 years of age. Results: There were no differences in visual function as assessed by the Bailey-Lovie acuity chart, transient visual evoked potential or sweep visual evoked potential testing between children whose mothers received DHA versus placebo. Children whose mothers received DHA versus placebo performed significantly better on the Sustained Attention Subscale of the Leiter International Performance Scale (46.5 ± 8.9 vs 41.9 ± 9.3, P < .008) but there were no statistically significant differences between groups on other neuropsychological domains. Conclusions: Five-year-old children whose mothers received modest DHA supplementation versus placebo for the first 4 months of breastfeeding performed better on a test of sustained attention. This, along with the previously reported better performance of the children of DHA-supplemented mothers on a test of psychomotor development at 30 months of age, suggests that DHA intake during early infancy confers long-term benefits on specific aspects of neurodevelopment. © 2010 Mosby Inc. All rights reserved.