Epistemonikos: El más rápido y confiable buscador de evidencia en salud

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BeSt (Behandel-Strategieën [“treatment strategies”])

Este hilo de publicación incluye 35 referencias

NEO-RACo (New Finnish RA Combination Therapy)

Este hilo de publicación incluye 10 referencias

IDEA (Infliximab as Induction Therapy in Early Rheumatoid Arthritis)

Este hilo de publicación incluye 9 referencias

Bejarano V, et al. 2010

Este hilo de publicación incluye 1 referencias

ASPIRE (Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset)

Este hilo de publicación incluye 5 referencias

Bone loss in patients with active early rheumatoid arthritis: Infliximab and methotrexate compared with methotrexate treatment alone. Explorative analysis from a 12-month randomised, double-blind, placebo-controlled study

Autores » Haugeberg G , Conaghan PG , Quinn M , Emery P

Revista » Annals of the rheumatic diseases

Año » 2009

Enlaces » Pubmed DOI

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Objective: To examine the effect of infliximab plus methotrexate (MTX) compared with placebo plus MTX on bone loss in patients with early rheumatoid arthritis (RA) in a double-blind randomised study design. Further, to explore the associations between bone loss and markers of RA disease. Methods: All 20 patients with RA (10 patients in each treatment group) had active, early RA. Bone mineral density (BMD) was assessed at the hand, lumbar spine (L2-4) and hip by dual energy x-ray absorptiometry at baseline and 12 months' follow-up. Clinical data were collected at regular visits. Results: BMD loss was significantly reduced in the infliximab group compared with the placebo group at the femoral neck (20.35% vs 23.43%, p=0.01) and total hip (20.23% vs 22.62%, p=0.03) but not at the hand (22.09% vs 22.82%, p=0.82) and spine (20.75% vs 21.77%, p=0.71). Measures of disease process and joint damage were found to be independently associated with bone loss. Conclusions: This study provides strong evidence of a causal link between inflammation and bone loss in RA. The anti-inflammatory effect of infliximab was potent enough to arrest inflammatory bone loss at the hip but not at the spine and hand.