Estudio primario

No clasificado

Clinical Study on Blood Pressure Variability, Montreal Cognitive Assessment and Arteriosclerosis Index in Patients with Cerebral Small Vessel Disease Treated with Integrated Traditional Chinese and Western Medicine by Invigorating Kidney and Removing Blood Stasis

Año 2022
Autores Wang T , Liang F , Wang Y , Huo Q , Wang B
Revista Evidence-based complementary and alternative medicine : eCAM
Enlaces Pubmed , PMC , DOI
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OBJECTIVE:

To explore the clinical improvement in blood pressure variability, Montreal Cognitive Assessment, and angiosclerosis index in patients with cerebral small vessel disease treated with integrated traditional Chinese and Western medicine.

METHODS:

A randomized controlled study of patients with cerebral small vessel disease who were treated in our hospital from November 1, 2018, to January 31, 2022. The enrolled patients were randomized into 2 groups according to the random numbers: an observation group treated with integrated traditional Chinese and Western medicine and a control group treated with Western medicine only. Blood pressure variability, Montreal Cognitive Assessment (MoCA), and angiosclerosis index were compared between the two groups.

RESULTS:

There were 71 qualified cases in the observation group and 58 qualified cases in the control group. Before treatment, the indicators between the two groups were comparable (P > 0.05). After treatment, the mean values of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly decreased (P < 0.05); the decrease of 24hSBP-coefficient of variation (CV), daytime SBP (dSBP)-CV, 24hSBP-standard deviation (SD), and dSBP-SD in the observation group was significantly better than that in the control group; the MoCA scores of the observation group were significantly higher than those of the control group ((P < 0.05); the ABI and PWV were significantly different between the two groups (P < 0.05); TC, TG, HDL-C, and LDL-C in observation group decreased after treatment, and HDL-C increased significantly (P < 0.05).

CONCLUSION:

Integrative traditional Chinese and Western medicine treatment can further reduce the blood pressure variability, especially systolic blood pressure; improve the MoCA score and cognitive function, increase the ankle-brachial index, reduce pulse wave velocity and the degree of arteriosclerosis; and improve lipid metabolism a comprehensive intervention role.

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Estudio primario

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综合方式干预对高血压前期患者周围动脉硬化的影响 / Effects of comprehensive intervention on peripheral arteriosclerosis in patients with prehypertension

Año 2014
Autores Zhang Zhi
Revista 中外医学研究 / Chinese and foreign medical research
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OBJECTIVE:

To analyze the effect of comprehensive intervention on arteriosclerosis in patients with prehypertension, and provide data reference for its clinical diagnosis and treatment.

METHODS:

The clinical data of 90 patients with prehypertension who were treated in the author's hospital from August 2011 to October 2012 were retrospectively analyzed. The 90 patients were randomly divided into three groups: non-intervention group, lifestyle group, comprehensive intervention group, 30 cases each. Observe the differences in blood pressure changes and arteriosclerosis among the three groups of patients after one year of treatment.

RESULTS:

After comparison, the situation of the non-intervention group did not improve significantly or even deteriorated and arteriosclerosis after 1 year; the situation of the lifestyle group improved slightly but not obviously; while the situation of the comprehensive intervention group improved significantly, 1 Years later, the average values ​​of the patients basically reached the normal range.

CONCLUSION:

The comprehensive intervention method in clinical practice to assist the treatment of prehypertensive patients can effectively control the blood pressure of patients, and at the same time effectively prevent the occurrence of prearteriosclerosis. The effect is remarkable and it is worthy of widespread promotion.

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Ensayo clínico exploratorio del efecto de atorvastatina en la modulación de la rigidez arterial y de los marcadores biológicos implicados en la arteriosclerosis en pacientes con lupus eritematoso sistémico (LES)

Año 2011
Autores Dr. Miguel Yebra Bango
Registro de estudios EU Clinical Trials Register
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INTERVENTION:

Product Name: Atorvastatina Product Code: ATOR Pharmaceutical Form: Film‐coated tablet INN or Proposed

INN:

Atorvastatina

CONDITION:

LUPUS ERITEMATOSO SISTÉMICO (LES) ; MedDRA version: 13 Level: LLT Classification code 10025139 Term: Lupus eritematoso sistémico

INCLUSION CRITERIA:

‐ Pacientes adultos (18 años) con diagnóstico confirmado de LES de acuerdo a los criterios de la ACR. ‐ Pacientes que se prevea que permanecerán estables durante el periodo de estudio. ‐ Actividad de la enfermedad: leve, leve‐moderada ‐ Pacientes que por su situación clínica se prevea que no requieran modificaciones en su tratamiento durante el periodo en el que se lleva a cabo el estudio. ‐ Pacientes que se prevea que no van a modificar los factores de riesgo cardiovascular y/o iniciar tratamiento para los mismos (tensión arterial, tabaquismo, peso, glucemia y colesterol). ‐ Los pacientes deben estar dispuestos a dar su consentimiento informado por escrito y ser capaces de hacerlo conforme a ICH/GCP y a la legislación local, antes de cualquier procedimiento de estudio. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elde

PRIMARY OUTCOME:

Main Objective: Evaluar el efecto del tratamiento con Atorvastatina a corto plazo sobre marcadores de ateroesclerosis subclínica en pacientes con Lupus Eritematoso Sistémico. Primary end point(s): Variable primaria: ; Se ha determinado una variable principal con dos componentes. La variable primaria evaluara el cambio en la visita 2‐semana 8 respecto a la basal de:; ‐ El número de células progenitores endoteliales circulantes (como potencial marcador biológico de riesgo cardiovascular) ; ‐ La rigidez arterial medida con técnicas no invasivas (velocimetría doppler). ; ; Variables secundarias:; ‐ Se determinará el cambio en el número de células progenitoras endoteliales circulantes (como potencial marcador biológico de riesgo cardiovascular) y de la rigidez arterial medida con técnicas no invasivas (velocimetría doppler) con respecto a la basal en la visita 3‐semana 20. ; ‐ Cambio respecto a la basal en los siguientes factores de riesgo cardiovascular medido en la visita 2‐semana 8 y la visita 3‐semana 20: peso, IMC (índice de masa corporal), perímetro abdominal, tabaquismo, perfil lipídico, diabetes melitus, hipertensión, edad, antecedentes familiares, homocisteina, proteína C reactiva (ultrasensible), cifras de urea/plasma, creatinina, cociente microalbúmina/creatinina. ; ‐ Cambio con respecto a la basal en la actividad de la enfermedad en la visita 2‐semana 8 y la visita 3‐semana 20, medida mediante el índice SLEDAI.; ‐ Cambio con respecto a la basal en la puntuación del índice de cronicidad (SLICC/ACR) en la visita 2‐semana 8 y la visita 3‐semana 20.; ‐ Cambios en el tratamiento concomitante: antimaláricos, esteroides, otros inmunosupresores en en la visita 2‐semana 8 y la visita 3‐semana 20.; ‐ Seguridad y tolerancia Secondary Objective: Valorar el impacto del tratamiento con Atorvastatina sobre: ; ‐ La arterioesclerosis subclínica determinada mediante la rigidez arterial, el grosor de la íntima‐media y la existencia de placa carotidea.; ‐ Marcadores biológicos: Número de células progenitoras endoteliales circulantes y marcadores inflamatorios solubles. ; ‐ Factores de riesgo cardiovasculares.; ‐ Factores de riesgo relacionados con el LES.

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Cardiovascular Disease in FH Heterozygous

Año 2013
Registro de estudios clinicaltrials.gov
Enlaces ClinicalTrials.gov

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The objective of this project is to establish the current prevalence of cardiovascular disease in adult subjects suffering from genetically diagnosed HF, and to know the impact that drug treatment has course in cardiovascular disease when compared with that of their affected parents with a much longer period of exposure to hypercholesterolemia

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Estudio primario

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Pitavastatin or bezafibrate intervention, assessment of antiarteriosclerotic effect (PIONEER)

Año 2008
Registro de estudios UMIN Clinical Trials Registry
Enlaces UMIN-CTR

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Este artículo no tiene resumen

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Estudio primario

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Four blood pressure indexes and the risk of stroke and myocardial infarction in Japanese men and women: a meta-analysis of 16 cohort studies.

Año 2009
Revista Circulation
Enlaces Pubmed , DOI

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BACKGROUND:

Information has been sparse on the comparison of 4 blood pressure (BP) indexes (systolic BP [SBP], diastolic BP, pulse pressure, and mean BP [MBP]) in relation to long-term incidence of stroke and myocardial infarction, particularly in middle-aged and older Asians.

METHODS AND RESULTS:

The Japan Arteriosclerosis Longitudinal Study Group conducted a meta-analysis of 16 cohort studies in Japan. A total of 48,224 men and women 40 to 89 years of age participated at baseline, and 1231 stroke events and 220 myocardial infarction events occurred during an average 8.4-year follow-up. Multivariate-adjusted hazard ratios with a 1-SD higher value for each BP index were determined by Poisson regression. Analyses were also done in 4 age-sex groups. All 4 BP indexes were significantly related to all stroke risk. Stroke risk was most strongly related to MBP and SBP in both sexes and most weakly related to pulse pressure. Both stroke subtypes, ischemic and hemorrhagic, were most strongly related to MBP and SBP in both sexes. In addition, in men and women 70 to 89 years of age, MBP or SBP showed the strongest relation to all stroke risk. Myocardial infarction risk was most strongly related to SBP or MBP in both sexes. For any end points in any age-sex groups, pulse pressure was not the strongest predictor.

CONCLUSIONS:

The long-term incident risk of stroke and myocardial infarction associated with high BP in East Asian populations should be assessed mainly on the basis of SBP. MBP also may be an important predictor, but pulse pressure is a less important predictor for cardiovascular disease risk.

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[Diagnostic clues in pulsatile tinnitus (somatosounds)].

Año 2007
Autores Herraiz C , Aparicio JM
Revista Acta otorrinolaringológica española
Enlaces Pubmed

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Pulsatile tinnitus is a sound from within the body, mostly of vascular origin, that stimulates the patient's hearing in the same way as an external sound does, generally at the same pace as the pulse. Although not frequent, the diagnosis of its cause is crucial because of its potential severity in some cases. This article describes some of the diagnostic clues for arterial causes (arteriosclerosis, aberrant carotid artery, arteriovenous fistula or malformations, increased vascularization in Paget's disease) and venous causes (benign intracranial hypertension, high jugular bulb). In some cases we have to rule out other systemic diseases as hypertension, cardiac arrhythmia or hyperthyroidism. A pathological otoscopy result may be secondary to a tympanic glomus. A guided medical history and an algorithm for complementary tests (magnetic resonance or angio-resonance imaging, computerized tomography, blood test, Doppler ultrasonography) may resolve the diagnostic puzzle of pulsatile tinnitus. We present our experience in 80 cases. The most frequent aetiology has been the arteriosclerosis of the carotid artery (17.5 %) and the benign intracranial hypertension syndrome (10 %).

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Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data.

Año 2010
Revista Circulation. Cardiovascular quality and outcomes
Enlaces Pubmed , DOI

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BACKGROUND:

The association of overweight/obesity with the incidence of cardiovascular diseases, especially stroke, has not been comprehensively examined in relatively lean populations in which stroke is more prevalent than coronary heart disease.

METHODS AND RESULTS:

Pooled individual data from 16 Japanese cohorts comprising 45 235 participants ages 40 to 89 years without previous history of cardiovascular disease were studied. During follow-up, 1113 incident strokes and 190 myocardial infarctions were identified. At baseline, mean ages of men and women were 55.4 and 56.5 years and mean body mass indices (BMI) were 23.0 and 23.4 kg/m(2), respectively. Compared with those with BMI <21.0, incidence rates of cerebral infarction in subjects with BMI ≥ 27.5 were significantly elevated in both men (hazard ratio, 1.81; 95% confidence interval [CI], 1.28 to 2.56) and women (hazard ratio, 1.65; 95% CI, 1.23 to 2.21), adjusted for age, smoking, and drinking habit. Incidence of cerebral hemorrhage was also associated positively with BMI in both men (hazard ratio, 2.51; 95% CI, 1.21 to 5.20) and women (hazard ratio, 1.98; 95% CI, 1.12 to 3.52). Adjustment for systolic blood pressure, a mediating factor, significantly attenuated most BMI association with stroke in both sexes. For myocardial infarction, the hazard ratio was 3.16 (95% CI, 1.66 to 6.01) for BMI 27.5 or greater versus less than 21.0 only in men, which appeared partly mediated by total cholesterol and SBP.

CONCLUSIONS:

Overweight/obesity was associated with an increased risk of cerebral infarction and hemorrhage in men and women and myocardial infarction in men. Weight control may have the potential to prevent both stroke and myocardial infarction in Japan.

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Renal and vascular protective effects of telmisartan in patients with essential hypertension.

Año 2006
Autores Morimoto S , Yano Y , Maki K , Sawada K
Revista Hypertension research : official journal of the Japanese Society of Hypertension
Enlaces Pubmed , DOI

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It is known that the angiotensin receptor blockers (ARBs) have organ protective effects in patients with heart failure or renal impairment. Several studies have revealed that the ARB telmisartan has an organ protective effect, but there have been few studies directly comparing the effects of telmisartan and calcium antagonists, since most clinical studies on telmisartan have been conducted in treated patients or patients on combination therapy. The present study was conducted to compare the renal and vascular protective effects of telmisartan monotherapy and calcium antagonist monotherapy in untreated hypertensive patients. Forty-three patients with untreated essential hypertension were randomized to receive amlodipine (n=22) or telmisartan (n=21), which were respectively administered at doses of 5 mg and 40 mg once daily in the morning for 24 weeks. The patients were examined before and after treatment to assess changes of renal function, flow-mediated dilation (a parameter of vascular endothelial function), and brachial-ankle pulse wave velocity (baPWV; a parameter of arteriosclerosis). Before treatment, there were no significant differences in these parameters between groups. The decreases of urinary albumin excretion and baPWV, and the increase of flow-mediated dilation were significantly greater in the telmisartan group than the amlodipine group, while the antihypertensive effects were not significantly different between the two groups. In conclusion, these results suggest that telmisartan is more effective at protecting renal function and vascular endothelial function, and at improving arteriosclerosis than the calcium channel blocker in patients with essential hypertension.

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Estudio primario

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Relationship of mammographic intra-arterial calcifications and diabetes.

Año 1984
Autores Schmitt EL , Threatt BA
Revista Southern medical journal
Enlaces Pubmed

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Mammary intra-arterial calcification (MIAC) as a predictor of occult diabetes has been suggested in the medical literature. However, the incidence of arteriosclerosis and atherosclerosis increases with age, as well as with hypertension and diabetes. The mammograms of 169 known diabetic women were reviewed for MIAC. Of the 27 (16%) women who had MIAC, 85% were aged 60 or older. There is no support for a direct relationship between MIAC and diabetes mellitus; MIAC is part of the aging process, where the population is at a greater risk for hypertension and/or diabetes.

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